A Thanksgiving trip (for my wife's birthday) was taken to Northern California. San Francisco is a fun, unique city and next to NYC, one of my favorite US cities. We stayed at the (too posh) Mark Hopkins hotel. The location was great, with fantastic views and a well known roof top bar called The Top of the Mark. While the hotel was certainly beautiful with a helpful staff, it was a bit stuffy for our tastes. The city offers great things for visitors, too many to mention. A quick trip to Muir Woods, to walk amongst the Redwood forest was a lot of fun and made for some cool pictures. In addition, the restaurant scene in San Fran is incredible, so indulge to your heart's delight.
Then, we spent a couple of days in Napa at a sweet BnB called The Churchill Manor. This was ideal in every way. Comfortable rooms (with fireplace and clawfoot tubs), cheese/wine/crackers every afternoon and a hearty breakfast every morning. Add to this some of the best food we've had and some vineyard visits, and it all makes for a nice trip. We really enjoyed the tasting and tour at Cakebread, and a quick walk around the town of St. Helena.
It was a great way to spend the Thanksgiving week and holiday. Leaving on Monday and returning on Friday also made for easy travel with no crowds.